modification of the urodele testis resulting from germ-cell degeneration.

by Rufus Richard Humphrey in (Wood"s Hole, Mass.)

Written in English
Published: Pages: 165 Downloads: 311
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Edition Notes

From Biological Bulletin, 48.

Other titlesBiological Bulletin.
The Physical Object
PaginationPp. 145-165 :
Number of Pages165
ID Numbers
Open LibraryOL19484321M

Bone metastasis is a rare entity in germ cell tumor of testis and is a poor prognostic site. It is usually associated with synchronous metastasis at other sites. Till now very few cases of isolated bone metastasis of germ cell tumor of testis have been reported but none have reported scapular metastasis. We are reporting a case of nonseminomatous germ cell tumor of right testis that Author: Dipti Rani Samanta, Chaitali Bose, Roopesh Krishnappa, Saumyaranjan Mishra, Sulagna Mohanty, Ashish. Germ cell tumours may be composed of a single histologic subtype, but it is more common for them to be composed of two or more subtypes. This is a germ cell tumour specimen that is comprised of embryonal carcinoma (roughly 90%), yolk sac (7%) and seminoma (3%).   Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells. Sci. Rep. 7, ; doi: /srep ().Cited by: 7. stimulation resulted in an upregulation in the germ cell markers KIT and DDX4 and somatic cell markers FSHR and HS3BD1. To study the optimal culture conditions for germ cell differentiation in vitro, rat testicular cells were cultured in a 3D culture system. We found that the choice of medium has an effect on Leydig cell functionality.

  Germ cells arise from a small group of cells that express markers of pluripotency including OCT4. In humans formation of gonadal compartments (cords in testis, nests in ovary) takes place during the 1st trimester (6–8 weeks gestation). In the 2nd trimester germ cells can enter meiotic prophase in females whereas in males this does not occur until puberty. We Cited by: Many men come to Memorial Sloan Kettering because they have found a lump or swelling in one of their testicles. Your first appointment will include a complete examination of your testicles and abdomen. We will also do blood tests to measure certain protein levels (tumor markers) that . Artificial testis to study early gonadal development and germ cell differentiation. Author: Reda, Ahmed. Date: To study the optimal culture conditions for germ cell differentiation in vitro, rat testicular cells were cultured in a 3D culture system. We found that the choice of medium has an effect on Leydig cell : Ahmed Reda. (B) Position of the testis at the end of its scrotal journey in a form possessing permanent descent of the testis, e.g., man, dog, etc. (C) Testis-peritoneal relationship in a form which does not have a permanent descent of the testis — the testis is withdrawn into the peritoneal cavity at the termination of each breeding season.

  Abstract. When Sertoli and germ cells were co-cultured in vitro in serum-free chemically defined medium, functional anchoring junctions such as cell-cell intermediate filament-based desmosome-like junctions and cell-cell actin-based adherens junctions (e.g. ectoplasmic specialization (ES)) were formed within days. This event was marked by the induction of .   Testicular tumors can be classified as seminomatous and non-seminomatous germ-cell tumor (NSGCT) types. Mixed germ cell tumors contain more than one germ cell component and are much more common than any of the pure histologic forms representing 32%% of all germ cell tumors. The composition of these tumors varies. Here we present a rare Cited by: 6. KEY WORDS: germ cell, teratoma, teratocarcinoma, testis, stem cell From Aristotle to the Reinaissance Although it was appreciated from the antiquity that removal of gonads had evident consequences for the fertility and behaviour of men, the anatomy and function of the gonads were essentially unknown in the ancient times. Indeed, morphometric analysis of the adult rat testis has shown that each Sertoli cell is associated with ∼30–50 germ cells at each stage of the spermatogenic cycle in the epithelium (, ), illustrating not only that germ cell development relies heavily on the Sertoli cell but that extensive communications take place to coordinate the Cited by:

modification of the urodele testis resulting from germ-cell degeneration. by Rufus Richard Humphrey Download PDF EPUB FB2

Tlie multilllc testis in urodeles A4 modific,ation of the i~roclele testis resulting from gcrm-eel1 degeneration. K~SGSHIJRY, H.

The sperniatogeiicsis of Dcsmiopnathus fusea Jan A modification of the urodele testis resulting from germ-cell degeneration. Ibid. NOBLE, G. The biology of the Am-phibia.

McGraw-Hill Book Co., New York, N. AND I. WEBER. The spermato-phores of Desmognathus and other pletho-dontid salamanders. modification of that of Cope (), and. Testicular germ cell tumors account for 90% of primary tumors of the are the most common nonhaematologic malignancy in men years old.

They are divided into: testicular seminoma: 40% of germ cell tumors 1; non-seminomatous germ cell tumor: 60% of germ cell tumors. testicular embryonal cell carcinoma. Germ cell tumor is a rare cancer that can affect people at all ages.

As ofgerm cell tumors account for 3% of all cancers in children and adolescents years old. Germ cell tumors are generally located in the gonads but can also appear in the abdomen, pelvis, mediastinum, or brain.

Germ cells migrating to the gonads may not reach that. The “nurse cell” function of Sertoli cells in spermatogenesis was originally tacitly assumed on the basis of the anatomical relationships between cells in the testis.

In mammals, from very early in prenatal development to the onset of meiosis and to the ultimate production of spermatozoa, the relationship between the germinal cells and the Cited by: Another classic example of germ cell degeneration/apoptosis is the morphologic consequence of testosterone deprivation in the rat testis.

Degeneration of stage VII/VIII pachytene spermatocytes and round spermatids, in addition to spermatid retention are early indicators of intratesticular testosterone depletion (Fig. 8)(also see Weinbauer.

The three groups of germ cell tumours of the testis show characteristic chromosomal anomalies, which favor the model of separate pathogeneses. The chromosomal data on germ cell tumors of the infantile testis and spermatocytic seminomas are scarse. A History of Leydig Cell Research.

A modification of the urodele testis resulting from germ cell degeneration. Article. Jan ; Degeneration of spermatogonia was observed following. Abstract. Franz Leydig first described the testicular cells in that modification of the urodele testis resulting from germ-cell degeneration.

book bear his name. For the next 50 yr after their discovery, Leydig cells were the subject of further studies by light microscopy, and diverse speculations were offered about their possible by: A germ-cell tumor (GCT) is a neoplasm derived from germ -cell tumors can be cancerous or cells normally occur inside the gonads (ovary and testis).GCTs that originate outside the gonads may be birth defects resulting from errors during development of Specialty: Oncology.

Spontaneous germ cell degeneration occurs in the testis of the adult rat. Accumulating data supports the idea that this degeneration takes place via apoptosis.

We have determined that morphology, acridine orange staining and ultrastructural features of these cell deaths clearly take the form of by: Management of Germ Cell Tumors of the Testis LASOP SCIENTIFIC PROGRAM Tuesday, February 8, Mahul B. Amin, MD Professor & Chairman, Department of Pathology Cedars-Sinai Medical Center [email protected] GERM CELL TUMORS OF TESTIS • Occur in young adults (20 - 50s) • May present with metastasis or develop extensive metastasis.

Mixed Germ Cell Tumor of the Testis is made up of 2 or more different types of germ cell tumors; those that are both seminomas and nonseminomas. However, they grow and spread like nonseminomas, and for this reason, they are treated as nonseminomas.

The exact causes of testicular germ cell tumours are unknown. However, there are a few factors that increase the risk - failed testicular descent: failure of the testes to descend into the scrotal sac (normally the testicles descend in the first year of a baby’s life), having a family history of testicular germ cell tumours and background; testicular germ cell tumours are more common in.

Germ cell apoptosis after mild testicular hyperthermia: involvement of early (I–IV) and late stages (XII–XIV) Physical factors induces stage-specific activation of apoptosis differently then hormonal scrotal regions of groups of five adult male rats were immersed in a water bath at room temperature 22 °C (control) or at 43 °C for 15 min.

Animals were then Cited by:   Subcutaneous grafting of immature testis fragments from rodents and primates was introduced in as a strategy to investigate testis development (Schlatt et al., ).

Xenografting was later put forward as an approach for rescuing male fertility and was used to explore gonadotoxic or irradiation-induced damage (Arregui and Dobrinski, ).Cited by: Davis BE, Herr HW, Fair WR, Bosl GJ.

The management of patients with nonseminomatous germ cell tumors of the testis with serologic disease only after orchiectomy. J Urol ; (1): De Angelis R, Sant M, Coleman MP et al. Cancer survival in Europe by country and age: results of EUROCARE-5 – a population-based study. A practical approach to the reporting of germ cell tumours of the testis D.M.

Berney Department of Histopathology, St Bartholomew’s Hospital, Barts and The London NHS Trust, West Smithfield, London EC1A 7BE, UK Summary Germ cell tumours (GCT) present many different challenges for. Yossepowitch O, Baniel J. Role of organ-sparing surgery in germ cell tumors of the testis.

Urology ; Schmoll HJ, Souchon R, Krege S, et al. European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG).

Ann Oncol ;   The multidisciplinary approach to the management of germ cell tumors of the testis has resulted in survival rates of > 90% overall. This review summarizes the principal management of germ cell tumors of the testis, highlighting the indications for surgery, controversies surrounding the integration of surgery, and alternative management by: The Sertoli cells are critical regulators of testis differentiation and development.

In the adult, however, their known function is restricted largely to maintenance of spermatogenesis. To determine whether the Sertoli cells regulate other aspects of adult testis biology we have used a novel transgenic mouse model in which Amh-Cre induces expression of the receptor for.

Zheng T, Holford TR, Ma Z, et al. Continuing increase in incidence of germ-cell testis cancer in young adults: experience from Connecticut, USA, Int J Cancer ; Ekbom A, Richiardi L, Akre O, et al. Age at immigration and duration of stay in relation to risk for testicular cancer among Finnish immigrants in Sweden.

The types of junctions in the testis have some similarity to junctions in other epithelia, such as the gap junction (GJ), desmosome, and hemidesmosome.Interestingly, the testis has a unique junction, known as the ectoplasmic specialization (ES), that is not found in other epithelia and/or endothelia (Figure ).Furthermore, the BTB is a unique blood–tissue barrier that is Cited by: Activin A and transforming growth factor β (TGFβ) signaling have been implicated in the regulation of germ cell quiescence, as both Inhba and Tgfbr2 knockout mice display increased germ cell proliferation, concomitant with delayed G1/G0 arrest, in the fetal testis (Moreno et al.

; Mendis et al. Approximately % of all testis tumors are non-germ cell tumors of the testis. Three types will be considered, namely, Leydig cell tumors, Sertoli cell tumors, and gonadoblastomas. Leydig Cell Tumors. Epidemiology & Pathology Leydig cell tumors are the most common non-germ cell tumors of the testis and account for % of all testicular tumors.

Visit the post for more. Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window). a surgical fixation of the testis in the scrotal sac. penis. male organ in which the urethra passes to allow urine to be expelled from the body, as part of the urinary system; delivers spermatozoa to the female reproductive tract, as part of the reproductive system a germ cell secretion of the testicles.

spermatic cord. a covering around. Testicular cancer arising from male germ cell (sperm precursor) tumours is one of the most common forms of cancer for young men aged Treatment for this disease has a high degree of success, but there is much to be learned about why the incidence of this cancer continues to increase worldwide.

Tsuchiya identified gonadoblastoma locus near Y centromere; TSPY gene is most likely candidate TSPY is expressed in adult spermatogonia and fetal gonocytes and has vital functions in male stem / germ cell proliferation It is ectopically expressed in gonadoblastoma, seminoma, ITGCN, some nonseminomatous germ cell tumors.

Details of the image 'Mixed germ cell tumor of the testis (gross pathology)' Modality: Pathology (Gross pathology). Primary bilateral tumors of the testis may happen synchronously or asynchronously but tend to be of the same histologic type.

Seminoma is the most common germ cell tumor in bilateral primary testicular tumors, while malignant lymphoma is the most common bilateral tumor of the testis.The blood vessels and nerves to the testis arise in the abdominal cavity.

They pass through the inguinal canal, where they join with connective tissue to form a spermatic cord that suspends each testis in the scrotum. The left testis is suspended lower than the right.

Which of the following statements best describes the anatomy of the testes?Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G. Hematologic neoplasia associated with primary mediastinal germ-cell tumors.

N Engl J Med. May 17;(20); Ikdahl T, Josefsen D, Jakobsen E, Delabie J, Fosså SD. Concurrent mediastinal germ-cell tumour and haematological malignancy: case report and short review of literature.